Bruce Banner has been hidden by S.H.I.E.L.D. in a small Kentucky town to protect him from those who are after him and want to use the Hulk. At the same time, S.H.I.E.L.D. is trying to decypher who shot Banner in the head (which left his brain so damaged, his once vast intelligence dropped to the level of a small kid).
Banner lives with the town's elder reverend Mr. Bassey and his wife. They call him Bobby. And he believes they are his grandparents. Picking them was not by chance: Bassey and his spouse are undercover S.H.I.E.L.D. agents.
Unfortunately, Banner's peaceful life won't (like always) last. A secret organization has used the Hulk's blood and flesh to rebuild the Abomination and bring him back from the dead. This time, the strong Abomination will be a mindless, raging beast of destruction, governed by that organization.
The Hulk genes in the Abomination act like a homing device so the villain finds Banner effortlessly. Fortunately, agent Maria Hill from S.H.I.E.L.D. was in the area and gets "Bobby" mad to trigger the transformation right before the Abomination crash lands on our green friend.
A terrible battle among these two powerhouse monsters follows, almost destroying the humble town in the process. Other S.H.I.E.L.D. agents who were in the area help getting the townspeople to safety. But one called Buddy does not want to leave. He states his anger to Hill for causing this tragedy, and demands answers. But they are interrupted by armed gunmen wearing suits that allow them to go through walls.