Bruce Banner, Rick Jones, and Clay Quartermain are on the run from S.H.I.E.L.D. Bruce can't recall the events that led them to this point. A woman appears to him in a dream, proclaiming herself to be an angel of mercy. She claims to help people with particularly burdensome problems—by killing them.
During a stopover at a diner, Clay has an altercation with an angry trucker. Outside, Bruce is deep in thought when the high-tech RV they've been traveling in suddenly starts to run him over. It's being driven by the woman from his dream. Bruce grabs onto the underside of the RV and is dragged. Rick manages to jump aboard to stop the vehicle, only to find that no one is behind the wheel.
Meanwhile, S.H.I.E.L.D. picks up the tracking signal from a device placed on the stolen RV. Bruce, Rick, and Clay head to a hospital looking for Betty Ross, only to learn she left the day before with someone named Ramon. Bruce doesn’t remember how Betty ended up in the hospital and fears it may have been his fault.
The mysterious woman reappears at the hospital, and Bruce narrowly escapes being killed. Meanwhile, in Washington D.C., Senator Tidewater is approached by a shadowy man who claims to be an admirer. It is hinted that this man is the Leader.
Night falls, and Bruce transforms into the Hulk. Rick tries to strike a bargain with him, based on their mutual interest in locating Gamma bombs that are being mass-manufactured by the government. Just then, the woman appears again, attempting to put Hulk/Bruce out of his misery. She explains that she is a missionary from another planet before firing energy blasts from her hand to kill the Hulk.
Meanwhile, S.H.I.E.L.D. agents close in on the tracking device—only to discover it’s attached to the 18-wheeler driven by the angry trucker from the diner. The trucker has mere seconds to bail out before the agents fire on his trailer, destroying it. Inside, they find only toilet paper.
The Hulk redirects the woman’s energy back at her, causing her to lose form and turn into a pile of goo. The Hulk and the goo pile fight, with the Hulk eventually being immersed by it. He smashes into a gas station and is doused in leaking gasoline. He ignites a flare and burns the goo completely off, presumably destroying it.
The Hulk accepts Rick’s offer, agreeing that Bruce will need protection. They continue on their journey.
The story ends with the trucker hauling his decrepit trailer, grumbling about the turn his life has taken. He stops to pick up a hitchhiker—a woman. The angel of mercy.
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